Below are the resources Methapharm has created to aid those reconstituting Provocholine for methacholine challenge testing according to the most common dosing protocols.

US Package Insert Doses

Concentrations of:

25 mg/mL
10 mg/mL
2.5 mg/mL
0.25 mg/mL
0.025 mg/mL

USPI Dilution Aid

USPI Dilution Video

ATS Short (quadrupling) Doses

*Please note: the following is not contained in the US Product Insert.

Concentrations of:

16 mg/mL
4 mg/mL
1 mg/mL
0.25 mg/mL
0.0625 mg/mL

ATS Short Dilution Aid

ATS Short Dilution Video

ATS Long (doubling) Doses

*Please note: the following is not contained in the US Product Insert.

Concentrations of:

16 mg/mL
8 mg/mL
4 mg/mL
2 mg/mL
1 mg/mL
0.5 mg/mL
0.25 mg/mL
0.125 mg/mL
0.0625 mg/mL
0.03125 mg/mL

ATS Long Dilution Aid

Provocholine 100 mg Dilution Aid USA ATS Long with worksheet

ATS Long Dilution Video