Research & Clinical Trials
Since Provocholine is a diagnostic agent, there is great value to including methacholine challenge testing as part of clinical trial protocols. It can have a variety of applications depending on the question that is being asked.
Methapharm has experience providing technical support for clinical trials using Provocholine in the following areas:
- Study inclusion/exclusion criteria
- Quantifying a response to investigational medications
- Comparing inhaler devices
- Epidemiological studies
- Specific atopies (allergies)
- Consumer product evaluation
The FDA have issued two guidance’s where methacholine challenge testing is discussed specifically when used in clinical trials:
Research on asthma and other respiratory conditions has evolved over the years. Provocholine is frequently used as the primary outcome or in conjunction with other drugs/procedures. In recent years, research using Provocholine has been effectively used to rule out asthma in patients, especially children, given that family history and other variables are taken into consideration.